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2013 Pilot Projects
Epigenetic Modulation of H3Ke4me3 Mark as a Therapeutic Target for Alzheimer’s Disease
Project Leader: Leslie Thompson, Ph.D.
This study directly targets a biologically relevant epigenetic signature that may be an effective strategy for therapeutic intervention in Alzheimer’s disease. Given the high incidence of Alzheimer’s disease in human population which is increasing with aging populations, this work has significant relevance to public health. Further, this work may have broad therapeutic potential for other neurodegenerative diseases
Lipoxin A4 as Potential Biomarker and Treatment for Alzheimer’s Disease
Project Leader: Rodrigo Medieros
Inflammation plays both a protective and damaging role in Alzheimer’s disease, so to identify a long-lasting and effective treatment, it is important that we better understand the disease’s underlying processes. This project investigates the molecular mechanisms associated with the age-dependent imbalance between pro-inflammatory and anti-inflammatory/pro-resolution lipid pathways in AD. These studies may establish the lipoxin A4 pathway as an attractive target for the development of a novel biomarker and therapy for Alzheimer’s disease.