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Research and Mentorship Program (RAMP)

By 2050, it’s estimated that 20% of the US population will be 65 or older, exacerbating the current shortage of geriatricians and neurologists. UCI MIND is tackling this issue by collaborating with UCI School of Medicine to encourage medical students to specialize in geriatric medicine. One such initiative is the RAMP program, a summer research mentorship that pairs 2nd-year medical students with UCI faculty studying neurodegenerative diseases.

In partnership with UCI School of Medicine, UCI MIND launched the Research And Mentorship Program (RAMP) for medical students in the summer of 2020. The program, made possible by support from community philanthropist Dr. Lorna Carlin and the nonprofit HFC led by Seth Rogen and Lauren Miller Rogen, pairs medical students with UCI MIND faculty mentors to inspire scientific ideas and future careers in dementia research and care.  More than two dozen medical students have participated in the program; many of whom have been given the opportunity to publish or present their results.

ICTS Summer Medical Student Alzheimer’s and Aging Research Training (SMAART) T-35 Training Program

The UC Irvine Institute for Clinical and Translational Science (ICTS) NIA T-35 training program works in conjunction with RAMP to provide financial support for students while they participate in the summer program.  The program also provides funds to help facilitate the research projects.

RAMP Trainees

Toluwa Balogun

Mentor: Ariel Neikrug, PhD

Project: The Association Between Behavioral Activity Rhythms and Alzheimer's Disease Pathogenesis

Abigail Dichter

Mentor: Mehdi Abouzari, MD, PhD

Project: The Predictive Role of Hearing Loss in Alzheimer's Disease

Kim Hoang

Mentor: Joshua Grill, PhD

Project: Attitudes of Vietnamese Physicians Towards Novel Alzheimer’s Disease Drug Therapies

Tiffany Hu

Mentor: David Sultzer, MD

Project: Uncovering Drivers of Neuropsychiatric Symptoms in Down Syndrome-Associated and Late-Onset Alzheimer's Disease

Claire Joyner

Mentor: Patrick Chen, MD

Project: The effect of pre-existing age-related co-morbidities, cardiometabolic factors, and social determinants of health on cognitive outcomes and dementia risk post-traumatic brain injury.

Ellie Marlor

Mentor: Elizabeth Head, PhD

Project: Characterizing Sex Differences in Alzheimer's Disease Pathology in Down Syndrome

Ashish Ramesh

Mentor: Frank Hsu, MD

Project: Surgical and Endovascular Comprehensive Treatment Outcomes of Unruptured Intracranial Aneurysms Among Older Patients

Hena Sihota

Mentor: Bryce Mander, PhD

Project: Assessing and Comparing the Association Between Peripheral and Central Inflammatory Markers and Sleep Quality

Justin Torres

Mentor: Kevin T Beier, PhD

Project: Early changes in connectivity from the retrosplenial cortex to the entorhinal and their roles in the pathology of Alzheimer's disease

Jordan Zonner

Mentor: Ahmad Sajjadi Seyed, MD, PhD

Project: Exploring Digital Markers for Detection of ADRD using Deep Learning Models and Association Analysis

View more

2023 RAMP Mentee: Mio Jang

Mio Jang

Mentor: Bernard Choi, PhD

Project: Identifying Cerebrovascular Imaging Parameters as Preclinical Biomarkers of Alzheimer’s disease

2023 RAMP Mentee: Maxwell Lee

Maxwell Lee

Mentor: Claudia Kawas, MD

Project: Exploring Cardiorespiratory Fitness as a Protective Factor for Cerebral Perfusion in Elderly Patients

2023 RAMP Mentee: Ariana Moss

Ariana Moss

Mentor: Craig Stark, PhD

Project: Longitudinal Association of Biomarkers and Depression on the Onset and Progression of Alzheimer’s Dementia

2023 RAMP Mentee: Cindy Okamoto

Cindy Okamoto

Mentor: Bryce Mander, PhD

Project: Influence of Sleep on Alzheimer’s Disease Biomarkers and Cognitive Function Across Levels of Cognitive Status

2023 RAMP Mentee: Cynthia Tsang

Cynthia Tsang

Mentor: Elizabeth Head, PhD

Project: Assessing Alzheimer’s Disease Markers in Feline Brains

2023 RAMP Mentee: Casey Vanderlip

Casey Vanderlip

Mentor: Elizabeth Head, PhD

Project: Fibrinogen Brain Deposition Across the Lifespan in Down Syndrome

2023 RAMP Mentee: Joey Wong

Joey Wong

Mentor: Seyed Ahmad Sajjadi, MD, PhD

Project: Analysis of Genes Implicated in Risk for Limbic Predominant Age-Related TDP-43 Encephalopathy Neuropathologic Change (LATE) in the 90+ Study

2023 RAMP Mentee: Katherine Yanes

Katherine (Olivia) Yanes

Mentor: Melissa Lodoen, PhD

Project: Effects of Toxoplasma Gondii on the Neuroimmune Landscape and Pathology in Human Alzheimer’s Disease

2022 RAMP Mentee: Joseph Bishop

Joseph Bishop

Mentor: Mark Mapstone, PhD

Project: Connecting Metabolic Changes in Liver, Blood, and Brain of 5XFAD Mice

2022 RAMP Mentee: Sydney Burger

Sydney Burger

Mentor: Steven Tam, MD

Project: Alzheimer’s Disease and Related Disorders, Caregiver Training

2022 RAMP Mentee: Amber Duong

Amber Duong

Mentors: Ira Lott, MD and Elizabeth Head, PhD

Project: Amygdala Lewy bodies in Adults with Down Syndrome: Clinical Context

2022 RAMP Mentee: Hannah Nguyen

Hannah Nguyen

Mentor: Seyed Ahmad Sajjadi, MD, PhD

Project: Identifying the Risk Factors and Contribution of Arteriolosclerosis to Cognitive Impairment in the Oldest Old

2022 RAMP Mentee: Victoria Nguyen

Victoria Nguyen

Mentor: David Sultzer, MD

Project: Neuropsychiatric Symptoms and Alzheimer’s Disease Risk Differences in Racial and Ethnic Minorities

Jeremy Rouanet

Mentor: Elizabeth Head, PhD

Project: Identification and Characterization of Blood-based Biomarkers of AD in the DS Population

Lauren Houchin

Mentor: Kim Green, PhD

Project: Conduct Immunohistochemical Staining, Slide-Scanning, and Confocal Microscopy to Characterize the Pathology in Mouse Models of AD

Yueqi Ren

Mentor: Craig Stark, PhD

Project: Predicting Alzheimer’s Disease Status and Cognitive Decline Using Multi-Modal Machine Learning Methods

Isabella Sanchez

Mentor: Leslie Thompson, PhD

Project: On Huntington’s disease (Title for project?)

Raumin Neuville

Mentor: Claudia Kawas, MD

Project: The Relationship Between Cognitive Functioning and Neuropathology Among People Aged 100 and Older, or Centenarians

Catriona Lewis

Mentor: David Sultzer, MD

Project: Evaluate the Relationships Between Beta Amyloid Accumulation in the Brain and Mood/Anxiety Symptoms in Asymptomatic Older Adults at Risk for Alzheimer’s Disease

Eric Han

Mentor: Mark Fisher, MD

Project: The Relationship Between Cognitive Decline, Cerebral Microvascular Disease, and Uremic Toxins (compounds usually filtered and excreted by the kidneys) Among Patients with Chronic Kidney Disease

Publications

  • Vanderlip CR, Stark CEL; Alzheimer’s Disease Neuroimaging Initiative. Digital cognitive assessments as low-burden markers for predicting future cognitive decline and tau accumulation across the Alzheimer’s spectrum. bioRxiv [Preprint]. 2024 May 26:2024.05.23.595638. doi: 10.1101/2024.05.23.595638. Update in: Alzheimers Dement. 2024 Oct;20(10):6881-6895. doi: 10.1002/alz.14154. PMID: 38826456; PMCID: PMC11142177.
  • Ren Y, Shahbaba B, Stark CEL. Improving clinical efficiency in screening for cognitive impairment due to Alzheimer’s. Alzheimers Dement (Amst). 2023 Oct 29;15(4):e12494. doi: 10.1002/dad2.12494. PMID: 37908438; PMCID: PMC10613605.
  • Yanes KJO, Guanzon NA, Azevedo R, Wheeler DG, Gandhi SP, Lodoen MB. Toxoplasma gondii Infection of Alzheimer’s Disease Mice Reduces Brain Amyloid Density Globally and Regionally. J Infect Dis. 2024 Sep 10;230(Supplement_2):S165-S172. doi: 10.1093/infdis/jiae227. PMID: 39255396; PMCID: PMC11385590.
  • Lewis CK, Bernstein OM, Grill JD, Gillen DL, Sultzer DL. Anxiety and Depressive Symptoms and Cortical Amyloid-β Burden in Cognitively Unimpaired Older Adults. J Prev Alzheimers Dis. 2022;9(2):286-296. doi: 10.14283/jpad.2022.13. PMID: 35543002.

Interested in applying?

For more information about the RAMP and SMAART T-35 programs or questions on how to help sustain it, please contact Julie Kinjo at jkinjo@uci.edu