Skip to main content

Testing effective treatments as potential preventions

By Commentary, In the News, Participants

Contributed by Joshua Grill, PhD Since Wednesday’s announcement by Eisai and Biogen of positive topline Phase 3 results for their treatment lecanemab in early Alzheimer’s disease, the field has been markedly aligned. Most agree that we need to see the data but that this seems to be a clear win and an important step in a positive direction. Some debates have begun, and more will happen, about the size and meaning of the win—that is, the size of the drug’s disease-slowing effects and the clinical meaningfulness. These debates will be extremely important but will take time. Combined with recently published…

Read More

Eisai and Biogen announce positive Phase 3 results for lecanemab

By Commentary, In the News

Contributed by Joshua Grill, PhD Today, Eisai and Biogen announced that the topline results of their Phase 3 trial, known as CLARITY, were positive. CLARITY was a placebo-controlled double-blind study of the monoclonal antibody against the amyloid beta protein lecanemab in patients with Mild Cognitive Impairment or mild dementia due to Alzheimer’s disease. Lecanemab has been shown previously to reduce amyloid burden in the brain of patients with symptomatic Alzheimer’s disease. According to today’s press release, lecanemab was effective in slowing decline measured with the Clinical Dementia Rating Scale (CDR), compared to placebo. This scale has been suggested by the…

Read More

Watch out, Alzheimer’s! Big new grant at UCI, new drug trial at Hoag coming for you

By Carousel Slider, Commentary, In the News

UC Irvine, a longtime hub of Alzheimer’s investigation, has been awarded a $47 million grant from the National Institute on Aging to support a team developing next-generation mouse models for studying late-onset Alzheimer’s. … “It’s an incredibly exciting time, and there’s a lot of promise,” said Joshua Grill, director of UCI’s Institute for Memory Impairments and Neurological Disorders. … The project’s next phase will be co-directed by Frank LaFerla, dean of the School of Biological Sciences; Andrea Tenner, a Distinguished Professor of molecular biology and biochemistry; and Kim Green, a professor of neurobiology and behavior. [Subscription required, campus-wide access provided by UCI Libraries. Sign-up here: https://guides.lib.uci.edu/news/ocregister] To learn more, click here > Related posts: Antihypertensives…

Read More

UCI Alzheimer’s project wins $47 million grant from National Institute on Aging

By Carousel Slider, Commentary, In the News

Scientists will develop mouse models to help unravel most common form of disease What began with a $70,000 philanthropic gift 12 years ago has grown into the recipient of a $47 million National Institute on Aging grant for Alzheimer’s disease research at the University of California, Irvine. The funds will be parceled out over five years to a UCI team developing the next generation of mouse models for studying late-onset Alzheimer’s. By inserting human genetic data into the models, researchers can better understand the biology that leads to Alzheimer’s and set the stage for preclinical drug testing. “This grant –…

Read More

UCI is key member of multi-institutional, $126 million NIH brain mapping project

By Carousel Slider, Commentary, In the News

Campus to receive $10 million over five years for role in Cell Atlas Network The University of California, Irvine will participate in a five-year, multi-institutional, $126 million grant from the National Institutes of Health supporting the BRAIN Initiative Cell Atlas Network. The project aims to describe the cells that make up the human brain in unprecedented molecular detail, classifying them into more precise subtypes and pinpointing their location. As a full member of BICAN, UCI will receive $10 million to collect, process and characterize a broad range of adult brain specimens. An interdisciplinary UCI team, led by Xiangmin Xu, Ph.D.,…

Read More

Dr. Christian Salazar Speaks on the News for World Alzheimer’s Day

By Carousel Slider, Commentary, Community Events, In the News

UCI MIND In The News on World Alzheimer’s Day: Yahoo News and CBSLA report that Epidemiologist Dr. Christian Salazar of UC Irvine spoke to Chris Holmstrom and Marci Gonzalez about how Alzheimer’s disproportionately affects the Latino community. Watch the news broadcast here > Related posts: Hypertension Medications Which Help Ward off Memory Loss Continuing all this week, National Public Radio’s “Academic Minute” series features a UCI expert. This Friday, tune in to hear Jean K. Ho, postdoctoral scholar at the UCI Institute for Memory Impairments and Neurological Disorders, who studies how hypertension medications help ward off memory loss. Learn More…

Read More

First-Ever In-Person IMPACT-AD Course Held

By Commentary, Community Events

The Institute on Methods and Protocols for Advancement of Clinical Trials in ADRD (IMPACT-AD), is a comprehensive training program in clinical trials for Alzheimer’s disease and related dementias (ADRD). The course is directed by UCI MIND faculty member Joshua Grill and USC faculty member Dr. Rema Raman. Though in its third year, 2022 was the first time this innovative course could could be held in person and it was a resounding success. Throughout this past week, trainees from around the country, along with many of the nation’s best AD clinical trial investigators, stayed in La Jolla’s Estancia Hotel for an immersive, interactive, and comprehensive program. More than 100 investigators with…

Read More

Recognizing World Alzheimer’s Day

By Commentary, Community Events

World Alzheimer’s Day is today, Wednesday, September 21st. This day serves as a time to spread awareness, educate, and reflect on the need to develop better treatments and preventions for Alzheimer’s and other dementias. On this day, UCI MIND recognizes the millions of people around the globe who are living with or providing care for a person living with dementia. In particular, we thank all of the people who have donated their time, energy, and more, to the cause of research to discover solutions for Alzheimer’s disease and related dementias. Related posts: What do I do if I suspect that…

Read More

Spotlight on Care: Alzheimer’s Caregiving ranked #9 in 25 Best Alzheimer Podcasts!

By Commentary, Community Events, In the News

Feedspot, an RSS service recently released its top 25 Alzheimer’s Podcasts on the web and UCI MIND’s Spotlight On Care: Alzheimer’s Caregiving was ranked 9th among the podcasts they reviewed. Feedspot reviewed all sites based on traffic, social media, followers, domain authority and freshness. This ranking is particularly noteworthy since the many of the other podcasts have been producing content for several years, some for over a decade. Spotlight on Care was launched in 2021 and now has thousands of downloads and over 25 episodes with excellent advice and tips for dementia and Alzheimer’s caregivers. Please listen for free at spotlightoncare.com and let your…

Read More

25 Best Alzheimer Podcasts

By Carousel Slider, Commentary, In the News

UCI MIND’s podcast, Spotlight on Care: Alzheimer’s Caregiving, was featured in a list of the top Alzheimer’s podcasts by Feedspot. The best Alzheimer podcast list is curated from thousands of podcasts on the web and ranked by traffic, social media followers, domain authority & freshness. Watch our latest episodes at spotlightoncare.com. 9. Spotlight on Care: Alzheimer’s Caregiving  Irvine, California, US Welcome to Spotlight on Care, the podcast where we share stories, experiences, tips, and advice on caring for loved ones affected by Alzheimer’s and other dementias. Spotlight on Care is produced by the University of California, Irvine Institute for Memory Impairments…

Read More