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Training in Translational ADRD Neuroscience (TITAN) T-32

 

The TITAN-32 grant provides novel and necessary training to prepare predoctoral and postdoctoral scholars to lead the nation in research to reduce the impact of Alzheimer’s Disease and Related Dementias (ADRD). The multi-interdisciplinary training program focuses on nurturing a new generation of ADRD scientists, especially scientists with the unique training and skills necessary to design and perform translational research.

These training positions are funded by the NIA through the Training in Translational ADRD Neuroscience, or TITAN (T32AG073088), under the leadership of MPIs Joshua Grill and Elizabeth Head. Faculty affiliated with UCI’s NIA-funded Alzheimer’s Disease Research Center from the Schools of Biological Sciences, Medicine, Physical Sciences, Information & Computer Sciences and Social Sciences, and the Institute for Memory Impairments and Neurological Disorders (UCI MIND) are part of this interdisciplinary training program.

Leadership

Leader

Elizabeth Head, PhD

Department of Pathology and Laboratory Medicine
&
Department of Neurology

Dr. Head studied at the University of Toronto, Canada where she obtained her BSc, MA, and PhD in neuroscience in 1997 before moving to the University of California, Irvine and completing postdoctoral training in MIND. Until 2009, Dr. Head served as an Assistant Professor and Director of the Brain Tissue Repository for the UCI Alzheimer disease research center at the University of California, Irvine. Dr. Head then became a Professor and Associate Director of Education at the University of Kentucky’s Sanders Brown Center on Aging where she established a Down syndrome aging and Alzheimer disease research study. In 2019, Dr. Head returned to the University of California, Irvine and resumed her position as Director of the Brain Tissue Repository and now also serves as a Professor and Vice Chair for Research in the Department of Pathology and Laboratory Medicine.

Leader

Joshua Grill, PhD

Department of Psychiatry and Human Behavior
&
Department of Neurobiology and Behavior

Dr. Grill is Professor of Psychiatry and Human Behavior and Neurobiology and Behavior at UCI. He is the Carla Liggett and Arthur S. Liggett, MD, Endowed Chair, in honor of Frank M. LaFerla in the School of Biological Sciences at UCI. Dr. Grill holds leadership positions at UCI and in national Alzheimer’s disease research networks. He is the Chair of the Internal Ethics Committee for the Alzheimer’s Disease Cooperative Study. He co-Chairs the same Committee and co-leads the Recruitment Engagement and Retention Unit for the Alzheimer’s Clinical Trial Consortium (ACTC). He is the Co-Director of the Institute on Methods and Protocols for Advancement of Clinical Trials in ADRD (IMPACT-AD) and serves on the Scientific Advisory Boards for the Women’s Alzheimer’s Movement (WAM) and Hilarity for Charity (HFC). He is also the Clinical Trials section editor for Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.

TITAN Trainees

Adam Birnbaum

Mentor: Daniel Gillen PhD

Department: Statistics
Term: 2024-2025

Katherine Colcord

Katherine Colcord

Mentor: Maria Corrada, ScD

Department: Epidemiology & Biostatistics
Term: 2024-2025

Zahara Keulen

Zahara Keulen

Mentor: Matt Blurton-Jones, PhD

Department: Neurobiology & Behavior
Term: 2024-2025

Jerry Lou

Jerry Lou, MD

Mentor: William Yong, MD

Department: Pathology and Laboratory Medicine
Term: 2024-2025

Pooyan Mobtahej, Eng.D.

Mentor: Ahmad Sajjadi, MD, PhD

Department: Neurology
Term: 2024-2025

Jessica Noche

Jessica Noche, PhD

Mentor: Craig Stark, PhD

Department: Neurobiology & Behavior
Term: 2024-2025

Isabel Rivera

Isabel Rivera

Mentor: Jorge Busciglio, PhD

Department: Neurobiology & Behavior
Term: 2024

Jeremy Rouanet

Jeremy Rouanet

Mentor: Elizabeth Head, PhD

Department: Pathology and Laboratory Medicine
Term: 2024-2025

Veronica Woo

Mentor: Vivek Swarup, PhD

Department: Neurobiology & Behavior
Term: 2024-2025

View past trainees

2022 TITAN Trainee: Desiree Macchia

Desiree Macchia

Mentor: Kevin Beier, PhD

Department: Physiology & Biophysics
Term: 2023

2022 TITAN Trainee: Michael Neel

Michael Neel

Mentor: Ed Monuki, PhD

Department: Pathology and Laboratory Medicine
Term: 2023

2022 TITAN Trainee: Nima Shajarian

Nima Shajarian

Mentor: Al La Spada, PhD

Department: Pathology and Laboratory Medicine
Term: 2023

2023 TITAN Trainee: Jean-Paul Chadarevian

Jean-Paul Chadarevian

Mentor: Matt Blurton-Jones, PhD

Department: Neurobiology & Behavior
Term: 2022-2024

2023 TITAN Trainee: Cangao Chu

Cangao Chu

Mentor: Dan Gillen, PhD

Department: Statistics
Term: 2022-2023

2022 TITAN Trainee: Michael Starrett

Michael Starrett, PhD

Mentor: Liz Chrastil, PhD

Department: Neurobiology & Behavior
Term: 2022

2022 TITAN Trainee: Davis Woodworth

Davis Woodworth, PhD

Mentor: Seyed Ahmad Sajjadi, MD, PhD

Department: Neurology
Term: 2022

Roy Zawadzki

Roy Zawadzki

Mentor: Dan Gillen, PhD

Department: Statistics
Term: 2023-2024

Publications

Select TITAN Publications

  • Colcord KA, Gilsanz P, George KM, Kawas CH, Jiang L, Whitmer RA, Corrada MM. The Importance of Racially and Ethnically Inclusive Gait Speed Reference Values in Individuals 90 Years and Older: LifeAfter90. J Geriatr Phys Ther. 2024 Oct-Dec 01;47(4):202-213. doi: 10.1519/JPT.0000000000000416. Epub 2024 Sep 18. PMID: 39159436.
  • Chadarevian JP, Hasselmann J, Lahian A, Capocchi JK, Escobar A, Lim TE, Le L, Tu C, Nguyen J, Kiani Shabestari S, Carlen-Jones W, Gandhi S, Bu G, Hume DA, Pridans C, Wszolek ZK, Spitale RC, Davtyan H, Blurton-Jones M. Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy. Neuron. 2024 Aug 21;112(16):2686-2707.e8. doi: 10.1016/j.neuron.2024.05.023. Epub 2024 Jun 18. PMID: 38897209.
  • Woodworth DC, Nguyen KM, Sordo L, Scambray KA, Head E, Kawas CH, Corrada MM, Nelson PT, Sajjadi SA. Comprehensive assessment of TDP-43 neuropathology data in the National Alzheimer’s Coordinating Center database. Acta Neuropathol. 2024 Jun 19;147(1):103. doi: 10.1007/s00401-024-02728-8. PMID: 38896163; PMCID: PMC11186885.
  • Noche JA, Radhakrishnan H, Ubele MF, Boaz K, Mefford JL, Jones ED, van Rooyen HY, Perpich JA, McCarty K, Meacham B, Smiley J, Bembenek Bailey SA, Puskás LG, Powell DK, Sordo L, Phelan MJ, Norris CM, Head E, Stark CEL. Age-Related Brain Atrophy and the Positive Effects of Behavioral Enrichment in Middle-Aged Beagles. J Neurosci. 2024 May 15;44(20):e2366232024. doi: 10.1523/JNEUROSCI.2366-23.2024. PMID: 38561226; PMCID: PMC11097262.

Interested in applying?

Faculty with eligible candidates, please send a letter of nomination, description of the trainees’ project and curriculum vitae to Janet Ko at jko@uci.edu.