People ages 50 and older who have memory problems are needed for a new clinical trial for Mild Cognitive Impairment and Alzheimer’s disease at the University of California, Los Angeles and University of California, Irvine. The NEAT study is a clinical trial sponsored by the University of California “Cures for Alzheimer’s Initiative,” testing whether nicotinamide, a component of vitamin B3, can slow Alzheimer’s disease. Specifically, the 12-month study is investigating if a high daily dose of nicotinamide can affect the brain tangles associated with Alzheimer’s disease. The study also measures whether nicotinamide is effective in improving memory and other thinking…
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Facebook Live Series - ASK THE DOC: Alzheimer's Research Today! This monthly series features short talks and Q&A with experts from the University of California, Irvine Institute for Memory Impairments and Neurological Disorders (UCI MIND), 1 of 32 congressionally designated Alzheimer’s Disease Research Centers in the nation. Join UCI MIND on Facebook (@UCIrvineMIND) the first Friday of every month from 9:00-9:30 AM PST to learn about advances in research to improve Alzheimer’s disease diagnosis, treatment, and prevention. Episode 2: "What causes memory problems in older adults?" Dr. Ahmad Sajjadi is Assistant Professor of Neurology in the UCI School of Medicine.…
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Chelsea holding her father's hand at a psychiatric hospital, days before he passed away with Alzheimer's disease at the age of 61 In an interview with UCI undergraduate students, Chelsea Cox, Associate Director of Eduction for UCI MIND, shares her personal journey with Alzheimer's disease, her perspective on care and research, and how people - young and old - can get involved in the cause. "...No one should have to spend their final days that way. This experience is what motivated me to get involved in Alzheimer’s research and education. So that hopefully, one day, other people don’t have to…
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Tune in this Friday, March 1 @ 9AM for the next episode of our monthly Facebook LIVE series, "What causes memory problems in older adults?" This month, we're joined by Ahmad Sajjadi, MD, PhD, Assistant Professor of Neurology in the UCI School of Medicine. Dr. Sajjadi received his medical degree from Tehran University of Medical Sciences in Iran and his PhD from the University of Cambridge in the UK. Dr. Sajjadi is a behavioral neurologist who sees patients with memory concerns and also conducts research on Alzheimer’s disease and atypical forms of dementia. To attend live and ask questions, login…
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Maria Shriver discusses the importance of clinical trial participation and the EXERT Study of exercise in adults (65-89) with memory concerns. To learn more about this study, led by Carl Cotman, PhD at UCI MIND, call (949) 824-0008 or email research@mind.uci.edu.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https://www.mind.uci.edu/event/what-you-can-do-about-alzheimers/?instance_id=427
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Robert K. Chin/Alamy On February 11, the FDA issued a statement and 12 warning letters related to an aggressive change in the agency’s regulation of dietary supplements. The statement was outlined in the New York Times. The main objective of the new approach is enhanced protection of consumers from mislabeled and unproven claims about treatment of disease. At the core of the problem are a number of companies that specifically target people with Alzheimer’s disease and people who are concerned about developing Alzheimer’s disease. A list of the companies receiving warning letters, as well as links to the letters, can…
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Facebook Live Series - ASK THE DOC: Alzheimer's Research Today! This monthly series features short talks and Q&A with experts from the University of California, Irvine Institute for Memory Impairments and Neurological Disorders (UCI MIND), 1 of 32 congressionally designated Alzheimer’s Disease Research Centers in the nation. Join UCI MIND on Facebook (@UCIrvineMIND) the first Friday of every month from 9:00-9:30 AM PST to learn about advances in research to improve Alzheimer’s disease diagnosis, treatment, and prevention. Episode 1: "Can poor sleep cause Alzheimer's?" Bryce Mander, PhD, is Assistant Professor of Psychiatry & Human Behavior at UCI. He received his…
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Leslie Thompson, PhD, Chancellor's Professor of Psychiatry & Human Behavior, Neurobiology & Behavior (Photo credit: Steve Zylius/UCI) UCI News, January 30, 2019 - "Leslie Thompson of the Sue & Bill Gross Stem Cell Research Center and UCI MIND has been awarded $6 million by the California Institute for Regenerative Medicine to continue her CIRM-supported efforts to create stem cell treatments for Huntington’s disease. The funding will allow the Thompson lab to conduct the late-stage testing needed to apply to the U.S. Food and Drug Administration for permission to start a clinical trial in people. The therapy involves transplanting stem cells…
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Eric Doran, Manager of UCI MIND’s Down Syndrome Program, has partnered with his longtime friend and playwright, Steven Oberman, to tell the true story of Dr. John Langdon Down, the man who first described Down syndrome. We interviewed Mr. Doran to learn more about the vision behind this new play, Blurred at the Edges, set to run in March of 2019 at the Diversionary Theatre in San Diego. Eric Doran, MS What is the vision behind Blurred at the Edges? Down syndrome is named after Dr. John Langdon Down, a British physician who first described the condition in 1866. Most…
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Contributed by Joshua Grill, PhD, Director of UCI MIND Colleagues at the UCSF Memory and Aging Center published a timely critique in JAMA on a concerning and increasing practice in the United States. “Pseudomedicine” is a practice whereby qualified healthcare professionals prescribe supplements or other therapies that are not covered by insurance, and therefore require cash payments, for personal financial gain. Pseudomedicine is especially problematic among older patients and family members concerned about memory loss and desperate for effective therapies to slow or stop the progression of Alzheimer’s disease. Other examples of pseudomedicine include recommendations for brain healthy diet plans…
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Carl Cotman, PhD A study was recently published in the journal Neurology about physical activity's relation to Alzheimer's disease and cognition in older adults. NPR asked UCI MIND founding director Dr. Carl Cotman to comment on this impressive study, noting that exercise might "'offset the ill effects of brain degeneration.' He adds that lifestyle interventions such as an increase in physical activity and movement can be powerful even in the presence of disease." Click here to read the article > Dr. Cotman is leading a national clinical trial of exercise at UCI MIND. The trial aims to evaluate whether 18 months…
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Bryce Mander, PhD Colleagues at Washington University School of Medicine published novel findings on the correlation between tau tangles, a hallmark of Alzheimer’s disease pathology, and sleep quality in people who were cognitively normal or who had mild cognitive impairment. On ALZFORUM, UCI MIND faculty member, Dr. Bryce Mander commented, “This is an important paper because it shows for the first time how tau is related to sleep deficits. That’s going to be important in advancing our understanding of how Alzheimer’s disease pathology affects sleep.” Dr. Mander, Assistant Professor of Psychiatry & Human Behavior at UCI, has published several important findings on…
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Washington Post article highlights need for Latino representation in Alzheimer's clinical studies Contributed by Christian Salazar, PhD, UCI MIND Associate Project Scientist Andres Martin lost his dad to a rare form of early-onset Alzheimer’s. He hopes a cure is found before his daughter, Alexis, grows up. (Sarah L. Voisin/The Washington Post) A rare form of Alzheimer's disease, caused by a gene mutation first discovered among people living in Jalisco, Mexico, develops at much earlier age than typical cases of Alzheimer’s disease. Andres Martin, a 31-year old Marine, has this 'Jalisco mutation', and is committed to raising awareness that the fight…
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Dr. Ira Lott, Director of the UCI MIND Down Syndrome Program, discussed the connection between Down syndrome and Alzheimer’s disease with the Orange County Business Journal this week. Dr. Lott and his team conduct critical research studies with volunteer participants to improve understanding of brain aging and dementia in Down syndrome. Click here to read the article > To learn more about studies in Down syndrome and Alzheimer’s disease, click here >
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Contributed by Joshua Grill, PhD, Director of UCI MIND In a new study, colleagues at the Alzheimer's Disease Research Center at Washington University have found that levels of the cerebrospinal fluid protein tau, one of the hallmark pathologies in Alzheimer’s disease (AD), is lower in African Americans compared to Whites. This was true both for older participants who did and did not have memory problems. The study is not the first to find such differences between African Americans and Caucasians and it has important implications to a number of important areas of AD research. First, there is a growing movement…
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