UCI MIND is proud to partner with Maria Shriver's Women's Alzheimer's Movement in researching why women are more likely than men to develop Alzheimer's disease. The LA Times recently covered this partnership and the UCI researchers who were awarded grants to study gender differences. For more, read the article found in the Daily Pilot>
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UCI MIND postdoctoral researcher Alessandra Martini presents her research on inflammation and cognition in AD at AAIC 2018: "We used the triple transgenic mouse model that was actually developed at UCI, and we are hoping to...use this protein as a possible biomarker or as a target for treatment."
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Postdoctoral researcher and Alzheimer's Association Research Fellowship Awardee Stefania Forner explains her research on synaptic changes in the human brain.
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Dr. Jeffrey Cummings, the inventor of the Neuropsychiatric Inventory and international leader in the field of Alzheimer’s disease clinical trials was awarded the Bengt Winblad Lifetime Achievement Award at the Alzheimer’s Association International Conference. To hear Dr. Cummings lecture about the state of Alzheimer’s disease clinical trials, register for the UCI MIND Southern California Alzheimer’s Disease Research Conference at bit.ly/alzconference
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Professors Andrea Tenner (seen here, middle) and Frank LaFerla, along with other members of UCI MIND’s Next Generation Animal Models grant presented their work at the Accelerating Medicines Partnership—Alzheimer’s Disease (AMP-AD) meeting at a pre-conference to the Alzheimer’s Association International Conference in Chicago on July 19 and 20.
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Sunil Gandhi (left) and Mathew Blurton-Jones (right)Steve Zylius / UCI Currently, 2 out of every 3 people with Alzheimer's disease are women. Last year, UCI MIND began a partnership with Maria Shriver's Women's Alzheimer's Movement. This partnership launched a grant competition focused on understanding the role of sex in Alzheimer's disease. UCI researchers Sunil Gandhi and Mathew Blurton-Jones have been awarded this year's $100,000 grant. Their research will focus on the role of microglia in the brains of men and women using induced pluripotent stem cells generated from skin cells donated by UCI ADRC participants, modern mouse models of the…
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This week, BioArctic Neuroscience, Esai, and Biogen made headlines when they announced via press release the topline and positive results of their Phase 2a study of the anti-amyloid antibody BAN2401. The press release indicated that the drug “demonstrated statistically significant slowing in clinical decline and reduction of amyloid beta accumulated in the brain” in patients with early Alzheimer’s disease. To be sure, this is welcomed news. Too often headlines for Alzheimer’s disease clinical trials are about “flops” and “failures.” So we should take this good news and embrace it. Unfortunately, there remain many questions to which we need answers before we…
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Dr. Arvid Carlsson passed away this past Friday at the age of 95. His research into dopamine led to the development of treatments for Parkinson's disease, a neurodegenerative disease that involves tremors and rigidity. Dr. Carlsson showed that dopamine was a neurotransmitter and that it is critical to movement. Dopamine is depleted in Parkinson’s disease and the drug L-dopa can be used to treat patients with this neurological disease. Dr. Carlsson's findings earned him the 2000 Nobel Prize in Physiology or Medicine, along with noted American researchers Dr. Eric Kandel and Paul Greengard. UCI MIND is grateful for the work…
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On Friday, we collaborated with our colleagues at USC, UCLA, and UCSD at the 2018 Southern California Alzheimer's Disease Centers Research Symposium!
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Recent scientific reports, one in the journal Neuron and another coming out in the journal Cell, present some intriguing new data indicating a link between human herpes viruses and Alzheimer’s disease (AD). Because the majority of AD cases cannot be attributed to genetics alone, there has been keen interest in finding other factors that affect the risk of developing AD. Head trauma and infections are two such factors that have received attention by researchers. With regard to infectious agents, speculation has often centered on the herpes viruses, especially herpes simplex virus 1 (HSV1). Human herpes viruses are neurotropic, which means they…
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