Local Supportive Service Families impacted by Alzheimer’s disease and related dementias in California need your help! Advocate to conserve Community-Based Adult Services (CBAS)/Adult Day Health Care (ADHC) programs statewide. You can voice your support by using the elected official contact list and talking points provided by our community partner, Alzheimer’s Orange County. DOWNLOAD ELECTED OFFICIALS LIST DOWNLOAD TALKING POINTS TIMELINE OF CBAS/ADHC CUTS National Research Funding As the current COVID-19 pandemic has shown, continued research is absolutely critical to understanding and responding to diseases, and Alzheimer's is no different. Please take a stand today. Send a message to your members of Congress urging them…
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Social engagement while drinking may be why long-lifers tend to have one to two drinks per day, says University of California, Irvine’s Claudia Kawas, M.D., whose 90+ Study found this sweet spot. … We asked our four longevity experts how studying the oldest of the old had changed their lives. Here are eight changes they’ve made—that you can make too. … Claudia Kawas, M.D., of UC Irvine. Cut back a little on coffee. “I’m a big coffee drinker, and our study showed that 200 to 400 mg of caffeine a day is the sweet spot.” Tries to take the stairs and park…
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Today is Juneteenth, the commemoration of the end of slavery in the United States. On this day in 1865, two and a half years after President Lincoln signed the Emancipation Proclamation, Union soldiers landed in Galveston, Texas. They brought news that the war had ended and the enslaved were now free. American and Juneteenth flags | Wikimedia Commons Today, the fight for Black equality continues. Systemic racism continues to affect healthcare, nutritional access, education, and socioeconomic status in Black communities, all of which increase risk for Alzheimer’s disease. This Juneteenth occurs amid the historic Black Lives Matter movement. It reminds…
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Your cloth face covering may protect them. Their cloth face covering may protect you. (CDC) Face coverings must now be worn statewide in indoor public spaces, workplaces, outdoor lines, public transportation and other high-risk settings under guidance issued today by Gov. Newsom and the California Department of Public Health. “We are seeing too many people with faces uncovered – putting at risk the real progress we have made in fighting the disease,” Newsom said. “California’s strategy to restart the economy and get people back to work will only be successful if people act safely and follow health recommendations.” The new…
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As COVID-19 cases spread across the state and nation, demand is growing for blood tests to identify people who may have been exposed to the novel coronavirus and developed antibodies to it. Such antibodies may mean these individuals have at least some immunity to the virus, formally named SARS-CoV2, and therefore may be able to return to work and school — and help jump-start the flagging U.S. economy. Results may also help identify COVID-19 antibody-positive people whose blood donations could be used to make convalescent plasma, an investigational treatment for seriously ill COVID-19 patients, according to the U.S. Food & Drug…
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Epidemiology professor Karen Edwards, department of Public HealthSteve Zylius / UCI UCI epidemiologist offers advice on healthy travel, recreation during the pandemic Despite the all-encompassing disruption of the coronavirus pandemic, time marches on, with summer just around the corner. For many, June signals the beginning of vacation season. But as COVID-19 continues to spread, where does summer travel stand? States are reopening and inviting tourists – and their dollars – to return. But is it safe to take a trip? What do we need to know about hotel or Airbnb lodgings? About eating in restaurants? About large public gatherings? Karen…
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Resources and information from the UCI School of Medicine Center of Excellence on Elder Abuse and Neglect, the USC Center for Elder Mistreatment, and the National Center on Elder Abuse. Today is World Elder Abuse Awareness Day (WEEAD). The International Network for the Prevention of Elder Abuse and the World Health Organization at the United Nations launched the first WEAAD on June 15, 2006 in an effort to unite communities around the world in raising awareness about elder abuse. Elder abuse is widespread, and older adults living with Alzheimer’s disease and related dementias are especially vulnerable. According to the National…
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Attendees at Acacia Adult Day Services center in Garden Grove play a game after breakfast. The center provides low-income elderly and disabled people meals, medical care, occupational therapy and social programs. Gov. Gavin Newsom has proposed eliminating funding for Adult Day Services programs to help cover a $54 billion gap for the 2020-21 fiscal year. (Lauren M. Whaley/Center for Health Reporting) A recent article from the OC Register highlights the critical need for advocacy to save Orange County's senior services. State budget cuts could end adult day care that helps thousands of local families. What can you do to help?…
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ASSIST Program pairs future health workers with homebound to address needs and loneliness. Once she starts talking, Geraldine Buchanan admits, she can keep right on going. About to turn 91 on Friday, Buchanan, for now, is a prisoner of the pandemic, stuck inside her Westminster home in an effort to stay safe from the spread of coronavirus. Talking on the phone is an escape. Buchanan’s loquaciousness is OK with Ryan Batten, a 22-year old UC Irvine nursing student who calls her at least once a week. Batten, set to graduate in June, is a good listener, something that figures to…
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Contributed by Christian Salazar, PhD, UCI MIND Project Scientist Racism is once again thrust into our national spotlight by the death of yet another unarmed Black American at the hands of police. Lamentably, the structures that create racism are deeply embedded in our society and have a direct impact on creating and maintaining health inequities. Indeed, numerous studies over decades have shown dramatic and persistent differences in health across racial groups. These disparities are in no small measure byproducts of racism. To combat racialized health disparities, we cannot ignore the multifaceted ways in which racism manifests in our society. We…
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The recent murders of George Floyd, Breonna Taylor, Ahmaud Arbery, and too many other people in the Black community are atrocities that both warrant and demand the current national and global response. Sadly, these recent events also serve as a reminder of historical atrocities done to Black people and other diverse communities in the name of science. Researchers, like political leaders, must use this time to further open our minds, our ears, and our hearts to combat racism. Racial and ethnic health disparities permeate our society and Alzheimer’s is no exception. Risk for Alzheimer’s disease and other dementias is higher…
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The journal Alzheimer’s Research & Therapy, in celebrating the 10th Anniversary of the journal included a list of their 10 most accessed papers of the last year. A manuscript by UCI MIND researchers Hayk Davtyan, Morgan Coburn, David Cribbs, and Mathew Blurton-Jones made the list. Their article, “Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice” had been accessed by researchers more than 14,000 times! Congratulations to their team. To read more, Dr. Davtyan spoke about the manuscript on page 7 of the Winter 2020 Newsletter.
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Dear Friends of UCI MIND, In light of the current events, UCI has decided to postpone its annual UCI Giving Day - scheduled for today, June 3 - to ensure we are giving space to the important messages that need to be communicated during this uncertain time. On behalf of the faculty and staff at UCI MIND, thank you for your ongoing support in the fight against Alzheimer's disease and related dementias. Sincerely, Joshua D. Grill, PhD Director of UCI MIND
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Message from the Director Dear Friends of UCI MIND, Since writing my last message for our Winter 2020 issue, we have all had our worlds turned upside down by COVID-19. At UCI MIND, we have faced challenges and have had to temporarily adapt our research programs. But, I know these challenges pale in comparison to those faced by members of our community. I’m especially concerned about the additional challenges faced by caregivers of people living with dementia, as well as the social isolation physical distancing can bring to older people who are living alone. We are eager to help…
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UCI MIND faculty member Masashi Kitazawa, PhD comments for Scientific American: "In a field where scientists have spent decades focused on genetics and the buildup of damaged protein fragments called beta-amyloid as causes of the disease...now many experts agree that air pollution plays a major role. This assessment is echoed by Masashi Kitazawa, a toxicologist at the University of California, Irvine, and an expert on environmental toxins. “Genetics is huge in Alzheimer's research, and for years almost no one wanted to look beyond genes,” he says. “But in the past three or four years the number of papers linking air pollution and cognitive decline…
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“If successful, we hope that treatments such as Aviptadil may change the chances of survival for these patients,” says Dr. Richard Lee, who is leading the trial at UCI. Carlos Puma for UCI Health UCI Health will initiate a clinical study of a drug to treat critically ill COVID-19 patients who face a high mortality rate because of acute inflammation that fills their lungs with fluid, a grave condition that even mechanical ventilation cannot improve. Aviptadil, which has a 20-year history of use in human clinical trials for lung ailments, will be employed in a phase 2b/3 clinical study…
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Irvine, CA - May 12, 2020 - A team of researchers from the University of California, Irvine and San Diego have been awarded $3.8 million by the National Institute on Aging to conduct an epigenomic analysis of neural circuits in the brain. By revealing molecular changes that occur during the course of Alzheimer's disease (AD), the team hopes to identify new therapeutic targets and molecular biomarkers for early detection and better treatment. The interdisciplinary research team is led by multiple principal investigators, including Xiangmin Xu, PhD, a professor of anatomy and neurobiology and director of the Center for Neural Circuit…
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Dr. Edwin S. Monuki watches microbiology lab scientist Jeanie Garcia process a patient's COVID-19 test sample. Photo Credit: Carlos Puma Read how through the efforts of the UC Irvine Health team, under the leadership of UCI MIND Faculty Member, Dr. Edwin Monuki, the medical center became the first hospital in Orange County to provide in-house COVID-19 testing on March 19 – more than two weeks ahead of schedule. http://www.ucihealth.org/…/racing-to-deliver-covid19-testing Dr. Monuki recently commented on antibody testing for the UCI MIND Blog and will participate in a virtual panel discussion tonight, May 14 at 7 PM PST. Click HERE to register.
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CalOptima, which provides health insurance to Orange County’s low-income residents, announced on Friday, May 8, it is working with UC Irvine and the county Health Care Agency to provide intensive training on infection control to staff at 12 nursing homes. … Dr. Susan Huang, who teaches about infectious diseases at UC Irvine, is working with researchers and clinicians to develop the tools and training, and will measure their effectiveness with diagnostic and antibody testing.
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Contributed by Daniel Nation, PhD, UCI MIND Faculty Member, Associate Professor of Psychological Science at UCI APOE4 is the strongest known genetic risk factor for Alzheimer's disease, the most common cause of dementia characterized by the accumulation of amyloid plaques and tau tangles. Although the predominant view has been that APOE4 conveys risk for Alzheimer’s dementia primarily through its effects on amyloid levels, prior work has also shown that APOE4 has adverse effects on the blood vessels of the brain. In a recent study published in Nature, colleagues at University of Southern California and I demonstrated that APOE4…
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During this time of uncertainty, communities, businesses and families are being impacted like never before. People are also coming together to help others in unprecedented ways. And while we all are spending more and more time at home, many of us are looking for ways to strengthen our communities while maintaining the current health and safety recommendations from the CDC. I’d like to invite you and your families to make a real difference without leaving your home or opening your wallet. I’m an OC Mom and researcher at UCI MIND. We are seeking volunteers to sign up for our “Consent-to-Contact”…
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Contributed by Edwin Monuki, MD, PhD, Warren L. Bostick Professor and Chair of Pathology and Laboratory Medicine at UC Irvine A recent article in the The New York Times focuses on an issue of grave concern among US health care providers - the flood of unapproved “lateral flow” tests for detecting COVID-19 antibodies. This flood resulted from an FDA decision to allow antibody testing without their usual approval process in order to accelerate the national response to COVID-19. Unfortunately (and not surprisingly), this also resulted in an antibody testing market that one interviewee in the NYT article called the “Wild West”.…
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NPR reports May 1, 2020 4:22 PM ET - The Food and Drug Administration has given emergency use authorization to the antiviral drug remdesivir to treat hospitalized patients with the coronavirus, President Trump on Friday told reporters at the White House. Gilead CEO Daniel O'Day said remdesivir maker Gilead Sciences is donating 1.5 million vials of the drug and will work with the federal government to distribute it to patients in need...
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https://youtu.be/r4ZpVGrBw5o Nicole Schartz, PhD, a postdoctoral scholar in Dr. Andrea Tenner’s lab, shares her experience of what’s happening in her lab and her perspective on the pandemic. Dr. Schartz is also a member of REMIND. Research and Education in Memory Impairments and Neurological Disorders, or REMIND, is a campus organization led by UCI MIND predoctoral and postdoctoral trainees. It aims to encourage collaboration among the next generation of scientists and clinicians, and promote community outreach and education on neurodegenerative diseases.
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While doing a video interview with TIME, Craig Stark, professor at the University of California, Irvine’s Center for the Neurobiology of Learning and Memory, said that his eighth grade son was on a headset chatting with his friends while gaming. “I’m great with that,” says Stark. Still, he adds, “if you’re gaming 20 hours a day, let’s get out, let’s do some other stuff, let’s not just talk to each other on a screen. But in terms of the notion that video games are actively rotting the brain? No, I don’t see any evidence for that.”
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The UCI Health Affairs Vice Chancellor is delighted to announce the launch of OC-COVID19.org, a new website devoted to providing timely, useful, evidence-based information about the novel coronavirus pandemic to our friends and neighbors across Orange County. UCI and UCI Health are at the forefront of Orange County's response to this national emergency. Every day there are stunning examples of remarkable, cutting-edge clinical care provided by the UCI Health family. Our services are driven by innovation and research taking place across the university. In this way, the UCI community is leading the way to solutions that are local and global.…
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A message from the CA Department of Aging: Join us April 22 for a Caring for Family & Friends Check-In Call: Caregiving from Afar Are You Caring for Family or Friends from Afar During COVID-19? Whether you are providing support to an older person across town, across the country, or in a Nursing Home or Residential Care Facility, COVID-19 guidelines have presented new challenges and concerns. Don’t miss out on a great opportunity to connect with caregiving experts! Wednesday, April 22th, at 1pm the California Department of Aging (https://aging.ca.gov) and the Alzheimer’s Association (https://www.alz.org) will host their 2nd of a…
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Police and fire agencies from across Orange County held a special drive-by parade at UCI Medical Center on Tuesday to show unity and support for the medical staff. Even though the salute was from a distance, they were able to touch hearts and lift spirits for those who are working long hours to get patients healthy. Meanwhile, Taco Bell's taco truck made a stop at the hospital to provide workers free lunch. … Next week, UCI Medical Center will get another dose of love, when the Anaheim Ducks send 200 meals a day.
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Amyloid accumulation not the only risk factor in Alzheimer’s risk Irvine, Calif. – April 8, 2020 – Amyloid is a key feature of Alzheimer’s disease, but the accumulation of these sticky proteins may not be the only risk factor for developing Alzheimer’s disease, according to a new study published this week. Other, modifiable risk factors, such as the amount of fats in our blood and how efficiently our bodies generate energy could also play important roles.
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#CANeedsYou covid19.ca.gov
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Contributed by Joshua D. Grill, PhD, Director of UCI MIND Dear friends, I read with interest this morning a blog post from the Director of the National Institute on Aging, Dr. Richard Hodes. Dr. Hodes refers to a “new normal,” in what can only be described the age of COVID-19. At UCI MIND, we are admittedly struggling a bit to adjust to this new normal. Our professional way of life—doing studies with older volunteers and gathering large and small community audiences to share our learnings and recommendations—has been turned upside down, as I know have been your own lives. While we…
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Orange County Aging Services Collaborative (OCASC) has compiled a list of local food resources available for seniors during the COVID-19 pandemic (list as of April 23, 2020): Senior Hour Grocery Stores Online Resources Regional Resources Delivery and Takeout Apps Restaurant To-Go Delivery Deals Pet Supply Delivery County Resource Food Source Spreadsheet By City South County Outreach Food Pantry Instructions (English) (Español) 211 Need Food Flyer (English / Español)
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Many local, national, and global agencies have been sharing information on COVID-19, so we have compiled several trusted sources of guidance for older adults. This is a rapidly-evolving situation and guidelines may change over time, so it's important to check major sources of information regularly.GLOBAL WHO: World Health Organization COVID-19 Quick Links Protect Yourself Questions and Answers Myth Busters Travel Advice NATIONAL CDC: Centers for Disease Control and Prevention Guidance for Adults at Higher Risk Who is at Higher Risk? Get Ready for Coronavirus Now Symptoms of Coronavirus (Español) How to Protect Yourself (Español) What to Do If You Get…
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Contributed by Emory University ADRC, Spanish translation by University of Kansas ADRC, Mandarin translation and Korean translation by UCI MIND ADRCPDF versions in multiple languages:
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Dear Friends of UCI MIND, I wanted to provide a brief update on the state of UCI MIND during the COVID-19 pandemic: Our faculty, staff, and trainees have responded admirably to this unprecedented and rapidly evolving situation. Whenever possible, research studies are being performed remotely for at least the next three weeks. If you are participating in a study or were anticipating doing so soon, you can expect to hear from the specific study team about how to proceed. If you are uncertain about your study, you can email questions to research@mind.uci.edu or call (949) 824-0008. We'll get back to you as soon…
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Last week, UCI MIND’s trainee-led organization REMIND hosted their 11th Annual Emerging Scientists Symposium. The event featured six trainee presentations from Gianna Fote in Drs. Leslie Thompson & Joan Steffan's lab, Heechul Jun in Dr. Kei Igarashi's lab, Arunima Kapoor in Dr. Dan Nation's lab, Dr. Sarah Hernandez in Dr. Leslie Thompson's lab, Dr. Ashley Keiser in Dr. Marcelo Wood's lab, and Dr. Davis Woodworth in Dr. Ahmad Sajjadi's lab. Presentations were followed by a keynote lecture from Dr. Carol Barnes from the University of Arizona and a trainee poster competition with over 30 innovative research projects on Alzheimer's disease…
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UCI MIND congratulates four members who have been named 2020 Physicians of Excellence. This distinction is given by Orange County Medical Association, and was published in Orange Coast magazine. There were more UCI Health physicians honored than from any other Orange County hospital or health system. Please join us in celebrating the achievements of these outstanding faculty. Click here to learn more >
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