Contributed by Alessandra C. Martini, PhD, Associate Project Scientist at UCI MIND Researchers have discovered that the majority of people with Down syndrome will have the pathology of Alzheimer’s disease – amyloid plaques and neurofibrillary tangles - in their brains by 40 years of age. In this new study, conducted with colleagues at the University of Kentucky, we used autopsy tissue donated by research participants to analyze the role of microglia (the brain’s immune cells) in the development of Alzheimer’s disease in people with Down syndrome across different ages and disease stages. What we found is that people with Down…
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“Our findings suggest that older individuals experiencing cognitive decline have relatively stable ideological preferences, but these preferences lose their connection to political policy details. Future studies conducted during an election year may shed additional light on how this group of Americans is casting their ballot,” said UCI MIND faculty member Mark Fisher, MD. Study participants were 190 members of The 90+ Study (LINK), a UCI-led longitudinal investigation of the oldest-old, who are those aged 90 and older.
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Charles Limoli FLASH radiation therapy, also called FLASH-RT, can eliminate the debilitating side effects associated with traditional radiation therapy by delivering the same dose in tenths of seconds, and can remove tumors, according to a study published in Clinical Cancer Research. … Charles Limoli, PhD, a researcher and professor of radiation oncology at University of California Irvine It's not unreasonable to expect that in 10 years, this may become a widespread option for radiotherapy patients worldwide."
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Amanda McQuade, graduate student in Mathew Blurton-Jones’ lab at UCI MIND, discusses findings from their new study using induced pluripotent stem cells (iPSC), donated from participants at the UCI Alzheimer’s Disease Research Center, and CRISPR gene editing to improve understanding of the role of immunity in Alzheimer’s disease. Click below to view the video, and access the publication at this link: https://www.nature.com/articles/s41467-020-19227-5 Amanda McQuade, MS Amanda McQuade is a graduate student in the department of Neurobiology and Behavior working with Dr. Mathew Blurton-Jones. Her graduate work focuses on using CRISPR to study risk mutations for Alzheimer’s disease in human…
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UCI MIND & UCI School of Nursing present a live Q&A panel: Caring for the Caregiver Tuesday, November 10, 2020 4:00 - 5:30 pm PDT Live on Facebook & YouTube Join us for a virtual discussion and Q&A with experts on the unique challenges facing dementia caregivers during the COVID-19 pandemic. Panelists include Dr. Joshua Grill, director of UCI MIND, Drs. Alison Holman and Jung-Ah Lee, faculty in the UCI School of Nursing, and Dr. Lisa Gibbs, medical director of UCI Senior Health Center. Register online to receive live viewing instructions.
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The actual number of deaths linked to dementia may be about three times greater than what is reported on U.S. death certificates, according to a recent NIA-supported study. The findings were published online August 24, 2020, in JAMA Neurology. Previous studies have established that doctors and medical examiners may be underreporting Alzheimer’s disease and related dementias as an underlying cause of death on death certificates. To investigate whether the impact from the underreporting was substantial, a research team led by investigators at Boston University compared dementia-related deaths determined by a nationally representative study to what is reported on death certificates.…
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UC San Francisco, UC Davis, UC Irvine, National Asian Pacific Center on Aging (NAPCA), International Children Assistance Network (ICAN) in partnership with over twenty community partners serving diverse Asian Americans and Pacific Islanders (AAPI) communities in California and nationwide, is pleased to announce the launch of the Collaborative Approach for AAPI Research and Education (CARE) research registry. The CARE registry team reflect multiple diverse AAPI cultures and languages. CARE is an opportunity for AAPI to participate in important research that may affect ourselves, our parents, children and grandchildren. Some of the important research may contribute to finding cures for and/or ways to…
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Congratulations to UCI MIND investigators, Drs. Elizabeth Head and Mark Mapstone, on earning a 5-year $100 million grant to study biomarkers for Alzheimer’s disease in people with Down syndrome. The Alzheimer’s Biomarker Consortium – Down Syndrome (ABC-DS) evolved from the longstanding contributions of Dr. Ira Lott and Eric Doran who had the insight to include older people with Down syndrome in Alzheimer’s disease research. People with Down syndrome are at very high risk for Alzheimer disease as their extra copy of chromosome 21 leads to accelerated amyloid buildup with aging. The new grant will help researchers improve understanding of the unique disease progression…
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Contributed by Franklin Garcia, PhD, UCI MIND Postdoctoral Fellow “On this Research Diversity Day, I would like to share my early undergraduate experience that paved the way for my interest in aging research. Franklin Garcia, PhD, UCI MIND Postdoctoral Fellow The concept of pursuing a career in scientific research was new to me since, as a first-generation university student, I didn’t have mentors or older peers that could shed some insight or guidance. Fortunately, during my last two years as an undergraduate student at UC Irvine, I received mentorship from my research advisor, Prof. Frank LaFerla and the faculty…
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Alzheimer syndrom screening.The presentation is made by me based on real scientific knowledge in the public domain. (3-minute listen) After cases began emerging worldwide, thousands of clinical trials unrelated to COVID-19 were paused or canceled amid fears that participants would be infected. But now, some researchers are finding ways to carry on in spite of the coronavirus. "It's been a struggle of course," says Joshua Grill, who directs the Institute for Memory Impairments and Neurological Disorders at the University of California, Irvine. "But I think there's an imperative for us to find ways to move forward."
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