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11th Annual Symposium Highlights Emerging Scientists

By In the News
Last week, UCI MIND’s trainee-led organization REMIND hosted their 11th Annual Emerging Scientists Symposium. The event featured six trainee presentations from Gianna Fote in Drs. Leslie Thompson & Joan Steffan's lab, Heechul Jun in Dr. Kei Igarashi's lab, Arunima Kapoor in Dr. Dan Nation's lab, Dr. Sarah Hernandez in Dr. Leslie Thompson's lab, Dr. Ashley Keiser in Dr. Marcelo Wood's lab, and Dr. Davis Woodworth in Dr. Ahmad Sajjadi's lab. Presentations were followed by a keynote lecture from Dr. Carol Barnes from the University of Arizona and a trainee poster competition with over 30 innovative research projects on Alzheimer's disease…
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4 UCI MIND investigators among 2020 Physicians of Excellence

By Commentary, In the News
UCI MIND congratulates four members who have been named 2020 Physicians of Excellence. This distinction is given by Orange County Medical Association, and was published in Orange Coast magazine. There were more UCI Health physicians honored than from any other Orange County hospital or health system. Please join us in celebrating the achievements of these outstanding faculty. Click here to learn more >
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Dr. Mark Mapstone comments for The New York Times

By Carousel Slider, Commentary, In the News
Stalked by the Fear That Dementia Is Stalking You The New York Times (Kaiser Health News) - Feb. 20, 2020 I spoke to half a dozen experts, and none was in favor of genetic testing, except in unusual circumstances. “Having the APOE4 allele does not mean you’ll get Alzheimer’s disease. Plenty of people with Alzheimer’s don’t have the allele,” said Mark Mapstone, a professor of neurology at the University of California, Irvine. “And conversely, plenty of people with the allele never develop Alzheimer’s.”
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Revived UCI Sleep Center Focuses on Mental Issues

By Carousel Slider, Commentary, In the News
Orange County Business Journal - Feb. 17, 2020 Dr. Ruth Benca, who is chair of the Psychiatry and Human Behavior School of Medicine at the University of California, Irvine in 2018 restarted the UCI sleep center. She’s designed a new, 6,000-square foot facility in Newport Beach … and has recruited doctors from a variety of fields, such as Dr. Kevin Im, who won a 2014 national award for a sleep study, Dr. Rami Khayat, the center’s medical director and expert on the effects of sleep apnea on cardiovascular diseases, and Dr. Behrouz Jafari, an expert in pulmonology. “We’ve built this…
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Dominantly Inherited Alzheimer’s Network (DIAN) and Lilly announce disappointing results

By In the News
Contributed by Joshua D. Grill, PhD, Director of UCI MIND Early Monday morning (February 10, 2020), the Dominantly Inherited Alzheimer’s Network Trials Unit (DIAN-TU) and Eli Lilly & Company announced disappointing results from a clinical trial of the monoclonal antibody, solanezumab, against the beta amyloid protein that accumulates in the brain of people with Alzheimer’s disease (press release >). The DIAN includes only the rare families who carry genetic mutations that cause an early-onset (3rd, 4th, 5th decade of life) form of Alzheimer’s disease. Solanezumab is also being tested as part of the Anti-Amyloid treatment in Asymptomatic Alzheimer’s (A4) Study, which is ongoing…
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From Postdocs to PI’s: Training Scientists For Success

By Commentary, In the News
Faculty members Mathew Blurton-Jones, PhD, Kim Green, PhD, and Masashi Kitazawa, PhD, are principal investigators (PI) of productive, independent laboratories at UCI MIND all aiming to target the underlying cause of and develop effective treatments for Alzheimer’s disease (AD) and related disorders. How did they get to where they are now? After graduate school in 2003, they came together from different backgrounds to train with renowned scientist, Frank LaFerla, PhD, who continues to run a successful laboratory of his own at UCI MIND.   Blurton-Jones, Green, and Kitazawa reflect on their training experience and what they believe to be their…
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In Memory of Dr. Frieda Rapoport Caplan

By In the News
It is with great sadness that UCI MIND shares news about the passing of Dr. Frieda Rapoport Caplan, founder of Frieda’s Specialty Produce and a tremendous supporter of brain research. Frieda was 96 years of age when she passed on Saturday. She was a pioneer in many powerful ways. A leader in the U.S. wholesale produce business since 1962, Frieda was the first woman to own and run her own firm. Her specialty was introducing unusual produce to the U.S. market, bringing more than 200 fruits and vegetables from around the world to America. She marketed each new product with…
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VIDEO: 2020 WAM-UCI MIND Initiative

By Commentary, Community Events, In the News
Jan 14, 2020 Announcements and research updates from the The Women's Alzheimer's Movement - WAM and UCI MIND Initiative to fund sex disparities in #Alzheimers research at University of California, Irvine. Congratulations to Mathew Blurton-Jones, PhD and Sunil Gandhi, PhD from the UCI School of Biological Sciences and Anshu Agrawal, PhD from the UCI School of Medicine, recipients of seed funding grants made possible by WAM Founder Maria Shriver and the Living Legacy Foundation led by VP and Executive Director Alisha Ballard.
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Why I Support UCI MIND

By Commentary, In the News
Contributed by Keith Swayne, UCI MIND Leadership Council Outstanding Philanthropist Keith Swayne, center, with Honorary Chairs and 2019 Legacy award honorees for Ueberroth Family Foundation Ginny Ueberroth, left, and Vicki Booth, right.(Tony Lattimore and Carla Rhea) - Daily Pilot It is humbling to be recognized as Philanthropist of the Year, particularly when I think about the many individuals who are working to make a difference in the world. The OC National Philanthropy Day event brought together Orange County philanthropists and non-profit organizations to celebrate our shared vision of improving our community. This is what drives me. I wish to use…
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VIDEO: “What is the link between Down syndrome and Alzheimer’s?” with Dr. Ira Lott

By In the News
Facebook Live Series - ASK THE DOC: Alzheimer's Research Today! This monthly series features short talks and Q&A with experts from the University of California, Irvine Institute for Memory Impairments and Neurological Disorders (UCI MIND), 1 of 32 congressionally designated Alzheimer’s Disease Research Centers in the nation. Join UCI MIND on Facebook (@UCIrvineMIND) to learn about advances in research to improve Alzheimer’s disease diagnosis, treatment, and prevention. Episode 11: "What is the link between Down syndrome and Alzheimer's?" This month, we’re joined by Ira Lott, MD, Professor Emeritus of Pediatrics and Neurology at UCI School of Medicine. Dr. Lott is…
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Updates on Biogen’s Aducanumab from CTAD

By Commentary, In the News
Contributed by Joshua Grill, PhD On Thursday, December 5, attendees at the Clinical Trials in Alzheimer’s Disease (CTAD) Conference heard more from Biogen about its recently resurrected drug, aducanumab (see previous Blog). New data were presented that were consistent with what had previously been shared. Biogen claims that a single positive Phase 3 trial of aducanumab and a secondary analysis of data from a second, negative Phase 3 trial suggest a benefit among patients receiving the highest dose for the full duration of the study (18 months). In both cases, high dose aducanumab appeared to slow the rate of disease…
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What is the link between Down syndrome and Alzheimer’s?

By In the News
Tune in this Friday, December 6th @ 9AM for the next episode of our monthly Facebook LIVE series, "What is the link between Down syndrome and Alzheimer's?" This month, we're joined by Ira Lott, MD, Professor Emeritus of Pediatrics and Neurology at UCI School of Medicine. Dr. Lott is a child neurologist at UCI and CHOC Children's Hospital and Director of the UCI MIND Down Syndrome Program, which studies Alzheimer's disease in individuals with Down syndrome. His research has been supported by the NIH, the Alzheimer's Association, and the State of California, including the largest clinical research grant for Down…
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UCI MIND Investigators Named AAAS Fellows

By In the News
UCI MIND faculty members, Tallie Z. Baram, MD, PhD and Marcelo A. Wood, PhD are named among nine UCI researchers as fellows of the American Association for the Advancement of Science (AAAS). Dr. Baram, the Danette Shepard Chair of Neurological Science and Director of the Conte Center at UCI, is recognized for her distinguished contributions to the understanding of childhood and febrile seizures as well as early life adversity on brain development and their enduring consequences. Dr. Wood, Professor and Chair of Neurobiology & Behavior, is recognized for his distinguished teaching and contributions to the field of memory and addiction, particularly the…
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Dr. Ruth Benca and other leading experts discuss “The Future of Brain Health” (VIDEO)

By Commentary, Community Events, In the News
UCI MIND faculty member, Dr. Ruth Benca, discussed sleep, brain health, and Alzheimer’s disease at the October 2019 #MIHealthSummit in Washington, D.C., hosted by the Milken Institute. The session opens with a conversation with Maxine Waters, U.S. Representative of California, followed by a panel discussion among leading researchers and policymakers on the latest evidence regarding reducing risk for cognitive decline, including nutrition, exercise, sleep, socialization, and stress management. View the plenary session below.
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First-of-its-kind study links the sleeping brain to toxin-clearing

By Commentary, In the News
Contributed by Bryce Mander, PhD A new landmark study from researchers in Boston was published in Science this month. This study linked human brain waves during deep sleep, called “slow waves,” with the pulsating flow of cerebrospinal fluid (CSF) through the brain. Fultz et al., 2019, NPR   This study is important because it is the first to directly link sleeping brain waves with a mechanism thought to clear the brain of metabolic waste and toxins, called the “glymphatic system.” Prior studies in rodents indicate that the glymphatic system actively clears Alzheimer’s disease pathology, as well as other toxins and…
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Another hopeful outcome for Alzheimer’s treatment

By Commentary, In the News
Contributed by David Sultzer, MD, Professor of Psychiatry & Human Behavior This past weekend, China’s regulatory agency conditionally approved sodium oligomannate for the treatment of mild to moderate Alzheimer’s disease.  The approval was based on results from a 9-month treatment study of 818 people, and is the first approval globally of an Alzheimer’s drug in 16 years. Oligomannate (GV-971) is a plant-based complex sugar derived from ocean seaweed. It’s thought to adjust the microbiome in the GI tract, thereby tweaking amino acid levels in the body and reducing the toxic effects of brain inflammation that contribute to Alzheimer’s disease.  Results from…
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Biogen’s About Face

By Commentary, In the News
Contributed by Joshua Grill, PhD Yesterday morning, Biogen announced the company’s intention to file with the FDA for approval of Aducanumab, a monoclonal antibody that until recently had been in development as a potential disease-modifying therapy for Alzheimer’s disease. The news came as a shock to us, since two large Phase 3 clinical trials of Aducanumab had been halted for futility earlier in 2019. “Futility” is defined as an early indication that a trial is not likely to demonstrate a drug benefit. As a site for one of those trials, we – along with the research participants and the entire…
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For many of us, solving Alzheimer’s disease is personal

By Commentary, In the News
Contributed by Joshua Grill, PhD Dorene Rentz and her husband, Ray Berggren, at their home in Natick, Mass. Dr. Rentz helped design the cognitive tests used in the A4 Alzheimer’s clinical trial in which her husband is now participating. Photo credit: M. Scott Brauer for the Wall Street Journal Alzheimer’s disease is a public health crisis. UCI MIND investigators regularly speak in public to increase awareness of the magnitude of the problem and the urgency of our work (see Event Calendar). But many of us leave the clinic, laboratory, or office to face this crisis at home as well. In this excellent…
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Yes! A positive Phase 3 treatment study for symptoms of dementia

By Commentary, In the News
Contributed by David Sultzer, MD, Professor of Psychiatry & Human Behavior Last week, Acadia Pharmaceuticals announced findings from its trial of pimavanserin for treatment of delusions and hallucinations related to dementia: Participants treated with pimavanserin had better outcomes than those treated with placebo. The study design was different from usual treatment comparisons of drug and placebo.  In this trial, all participants with psychosis symptoms along with Alzheimer’s disease or another cognitive disorder were treated with pimavanserin for 12 weeks.  Those who showed improvement were then assigned to either continue taking the drug or cross over to placebo treatment.  The study…
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Another setback, yet another reason to redouble our efforts

By In the News
Contributed by Joshua Grill, PhD, Director of UCI MIND Late Thursday evening, Esai publicly announced a decision to halt a Phase 3 clinical trial of a candidate treatment for Alzheimer’s disease, elenebecestat. The decision was made based on a recommendation by the study's Data Safety Monitoring Board, which determined that the safety risks of the drug no longer justified continuing the study. Elenebecestat is a BACE (beta-site of the amyloid precursor protein cleavage enzyme) inhibitor that joins several other BACE inhibitors previously determined to lack adequate safety for patient use. The field will grapple with this news and learn how…
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Summer 2019 MIND Matters Newsletter

By Commentary, Community Events, In the News
In this issue of MIND Matters: UCI MIND Scientists Discover Exercise Can Reprogram Genes Welcome, New Faculty & Staff New FDA Black Box Warning for Insomnia Medications Announcing the 10th Annual UCI MIND Gala Honorees... And more! Download Newsletter >   Upcoming Events:   Facebook LIVE Q&A Series: "What have researchers learned from brain donations?" Friday, September 6  |  9:00-9:30 am |  UCI MIND Facebook Page Follow @UCIrvineMIND to receive notifications when we go LIVE Live online Q&A with Edwin Monuki, MD, PhD, Professor and Warren L. Bostick Chair of Pathology in the UCI School of Medicine.  Attend the video live on our Facebook page or view archived…
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Commentary on the link between brain disease and sleep-wake systems

By Commentary, In the News
Contributed by Bryce Mander, PhD Getty Images Our colleagues at UCSF recently published findings in the journal Alzheimer’s and Dementia examining how tau pathology in different brain diseases – Alzheimer’s disease, progressive supranuclear palsy, and corticobasal degeneration – impacts brain cells that are in charge of keeping us awake. This study reported several important findings: In all three diseases, there was a reduction in brain cells that help promote cortical arousal. In all three diseases, tau pathology was quite substantial in several of the wake-promoting cells in the brainstem region. Tau pathology in the brainstem in Alzheimer’s disease was associated with…
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Commentary on Brain Scans for Alzheimer’s Disease

By Commentary, In the News
Contributed by Joshua D. Grill, PhD A recent article in the New York Times highlights an important set of conundrums regarding amyloid imaging for Alzheimer’s disease. Amyloid imaging can detect with relative certainty whether beta amyloid plaques, which are a pathological hallmark of Alzheimer’s disease, are accumulating in a person’s brain. Conundrum #1: Amyloid scans are not covered by insurance for people with cognitive problems. Research led by our friend Dr. Gil Rabinovici at UCSF has demonstrated that amyloid imaging can and does yield important guidance to clinical care. It can change diagnoses and instruct prescribing decisions (more on this >).…
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Association between anticholinergics and dementia prompt further study

By Commentary, In the News
iStock Recent stories, including one this week by Washington Post, have highlighted the possible impact of anticholinergic medications on dementia. Some studies note that these medications may have negative side effects that mimic dementia in older adults. Others show a possible increase in dementia risk when taking strong anticholinergics long-term. However, more research is needed to understand this potential link. It's important to speak with your doctor about all your medications regularly, discussing potential benefits, risks, and interactions, to help manage your health over time. To learn more about medications and Alzheimer's disease, view UCI MIND's recent Facebook LIVE episode with…
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