Illustration of SHQ. (a) Wayfinding level 6, where locations of three numbered checkpoints are first shown on a map. After the map disappears, participants have to navigate the boat to the numbered checkpoints in order, (b) Flare level 9, where participants navigate the boat from a starting location along the river, until they find a flare gun. Once found, the boat rotates by 180° clockwise and the participants are asked to shoot the gun in the direction of the starting location. Vaisakh Puthusseryppady, a post-doctoral scholar at the University of California, Irvine in the Department of Neurobiology and Behavior writes:…

Early life adversities can have a lifelong impact. Tallie Z. Baram, distinguished professor in the Departments of Anatomy & Neurobiology, Pediatrics, Neurology, and Physiology & Biophysics at the University of California, Irvine, determines why. Listen here > Prof. Tallie Z. Baram Prof. Tallie Z. Baram is the Danette Shepard Professor of Neurological Sciences, with appointments in several departments at UCI. Baram is a developmental neuroscientist and child neurologist and has focused her efforts on the influence of early-life experiences on the developing brain, and on the underlying mechanisms. She is studying this broad topic in two contexts: a) How early-life…

Findings show bone marrow transplantation may be a novel treatment approach July 12, 2022 Albert LaSpada, MD, PhD, distinguished professor of pathology, neurology and biological chemistry in the UCI School of Medicine, is one of the first researchers to examine whether some forms of ALS could be linked to the body's adaptive immune system, which builds up protection as it is exposed to foreign pathogens. Orange, Calif. — The immune system, along with the body's central nervous system, may play a fundamental role in amyotrophic lateral sclerosis (ALS), suggesting that bone marrow transplants may be an effective new treatment for the…

Leslie Thompson discusses how UCI’s collaborative approach can help usher in the next great advancement in healthcare July 11, 2022 “I’ve been involved in many very meaningful research projects in my career, but to be perfectly honest, this is huge for me, as I feel it ultimately can help the families that I so passionately care about,” says Leslie Thompson. Steve Zylius / UCI In February, UCI launched the Institute for Precision Health, a campus-wide, interdisciplinary endeavor that merges UCI’s powerhouse health sciences, engineering, machine learning, artificial intelligence, clinical genomics and data science capabilities. The objective is to identify, create…

Multisite team included UCI, University of Wisconsin–Madison, Wake Forest University July 13, 2022 “Our findings indicate that age-related increases in brain inflammation have a downstream effect on Alzheimer’s disease-related tau proteins and neuronal synaptic integrity,” says Bryce Mander, Ph.D., UCI assistant professor of psychiatry & human behavior and the study’s lead and co-corresponding author. “This results in deficits in the brain’s capacity to generate fast sleep spindles, which contribute to age-related memory impairment in older adults.” UCI School of Medicine Irvine, Calif., July 13, 2022 – A multisite research team from the University of California, Irvine, the University of Wisconsin–Madison and…