Ghazaleh Eskandar-Sedighi, PhD
Ghazaleh Eskandar-Sedighi, PhD, is a postdoctoral fellow, supervised by Mathew Blurton-Jones, PhD, professor of Neurobiology and Behavior in the Charlie Dunlop School of Biological Sciences. Dr. Eskander-Sedighi was recently awarded a prestigious Postdoctoral Fellowship in Alzheimer’s disease research from the BrightFocus Foundation. Ghazeleh’s research focuses on leveraging human stem cell-derived microglia and chimeric animal models to investigate protective microglial responses in the context of Alzheimer’s disease (AD). Her BrightFocus Foundation project specifically aims to take advantage of novel, multi-faceted stem cell and chimeric mouse models to study the impact of the protective microglial ApoE3 Christchurch mutation on disease pathogenesis in a novel mouse model of AD with combined amyloid and tau pathologies. Considering the significant advancements in the field of microglia-based therapeutics, the results from this 2-year, $200,000 fellowship could help the field clarify the potential therapeutic role of protective variants like APOE Christchurch against AD. Congratulations Ghazeleh!
